Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105–125
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چکیده
منابع مشابه
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125.
To identify sequence domains important for the neurotoxic and neuroprotective activities of the prion protein (PrP), we have engineered transgenic mice that express a form of murine PrP deleted for a conserved block of 21 amino acids (residues 105-125) in the unstructured, N-terminal tail of the protein. These mice spontaneously developed a severe neurodegenerative illness that was lethal withi...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2007
ISSN: 0261-4189,1460-2075
DOI: 10.1038/sj.emboj.7601507